KDM4A-PTCH2 Fusion FISH Probe
The KDM4A-PTCH2 Fusion FISH Probe is used to confirm a fusion of the KDM4A and PTCH2 genes. The fusion of the KDM4A and PTCH2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM4A-PTCH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-RERE | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-REOR | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-REGO | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-REGR | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-OROR | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-GORE | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-GROR | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM4A-PTCH2-20-AQAQ | 20 (40 μL) | 200 μL |
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PTCH2 Gene Summary
This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
Gene Name: Patched 2
Chromosome: CHR1: 45285515 -45308616
Locus: 1p34.1
KDM4A Gene Summary
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
Gene Name: Lysine Demethylase 4A
Chromosome: CHR1: 44115796 -44171189
Locus: 1p34.2-p34.1
Gene Diseases
The KDM4A PTCH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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