KDM4A-MPL Fusion FISH Probe
The KDM4A-MPL Fusion FISH Probe is used to confirm a fusion of the KDM4A and MPL genes. The fusion of the KDM4A and MPL genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM4A-MPL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-RERE | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-REOR | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-REGO | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-REGR | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-OROR | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-GORE | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-GROR | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM4A-MPL-20-AQAQ | 20 (40 μL) | 200 μL |
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MPL Gene Summary
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]
Gene Name: MPL Proto-oncogene, Thrombopoietin Receptor
Chromosome: CHR1: 43803474 -43820135
Locus: 1p34.2
KDM4A Gene Summary
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
Gene Name: Lysine Demethylase 4A
Chromosome: CHR1: 44115796 -44171189
Locus: 1p34.2-p34.1
Gene Diseases
The KDM4A MPL Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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