KDM2B-ORAI1 Fusion FISH Probe
The KDM2B-ORAI1 Fusion FISH Probe is used to confirm a fusion of the KDM2B and ORAI1 genes. The fusion of the KDM2B and ORAI1 genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM2B-ORAI1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-RERE | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-REOR | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-REGO | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-REGR | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-OROR | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-GORE | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-GROR | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM2B-ORAI1-20-AQAQ | 20 (40 μL) | 200 μL |
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KDM2B Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Lysine Demethylase 2B
Chromosome: CHR12: 121866899 -122018920
Locus: 12q24.31
ORAI1 Gene Summary
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Gene Name: ORAI Calcium Release-activated Calcium Modulator 1
Chromosome: CHR12: 122064454 -122079946
Locus: 12q24.31
Gene Diseases
The KDM2B ORAI1 Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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