KDM2A-RHOD Fusion FISH Probe
The KDM2A-RHOD Fusion FISH Probe is used to confirm a fusion of the KDM2A and RHOD genes. The fusion of the KDM2A and RHOD genes has been associated with Lung Squamous Cell Carcinoma, Lung Adenocarcinoma, Uterine Corpus Endometrial Carcinoma, Breast Invasive Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM2A-RHOD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-RERE | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-REOR | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-REGO | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-REGR | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-OROR | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-GORE | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-GROR | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM2A-RHOD-20-AQAQ | 20 (40 μL) | 200 μL |
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KDM2A Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Lysine Demethylase 2A
Chromosome: CHR11: 66886739 -67025550
Locus: 11q13.2
RHOD Gene Summary
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: Ras Homolog Family Member D
Chromosome: CHR11: 66824288 -66839488
Locus: 11q13.2
Gene Diseases
The KDM2A RHOD Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Lung Adenocarcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Breast Invasive Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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