KDM2A-PACS1 Fusion FISH Probe
The KDM2A-PACS1 Fusion FISH Probe is used to confirm a fusion of the KDM2A and PACS1 genes. The fusion of the KDM2A and PACS1 genes has been associated with Lung Adenocarcinoma, and Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM2A-PACS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-RERE | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-REOR | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-REGO | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-REGR | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-OROR | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-GORE | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-GROR | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM2A-PACS1-20-AQAQ | 20 (40 μL) | 200 μL |
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KDM2A Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Lysine Demethylase 2A
Chromosome: CHR11: 66886739 -67025550
Locus: 11q13.2
PACS1 Gene Summary
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]
Gene Name: Phosphofurin Acidic Cluster Sorting Protein 1
Chromosome: CHR11: 65837823 -66012213
Locus: 11q13.1-q13.2
Gene Diseases
The KDM2A PACS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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