KDM2A-MAP3K3 Fusion FISH Probe
The KDM2A-MAP3K3 Fusion FISH Probe is used to confirm a fusion of the KDM2A and MAP3K3 genes. The fusion of the KDM2A and MAP3K3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM2A-MAP3K3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-RERE | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-REOR | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-REGO | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-REGR | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-OROR | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-GORE | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-GROR | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM2A-MAP3K3-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP3K3 Gene Summary
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 3
Chromosome: CHR17: 61699800 -61773670
Locus: 17q23.3
KDM2A Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Lysine Demethylase 2A
Chromosome: CHR11: 66886739 -67025550
Locus: 11q13.2
Gene Diseases
The KDM2A MAP3K3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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