KDM2A-DDR2 Fusion FISH Probe
The KDM2A-DDR2 Fusion FISH Probe is used to confirm a fusion of the KDM2A and DDR2 genes. The fusion of the KDM2A and DDR2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM2A-DDR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-RERE | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-REOR | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-REGO | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-REGR | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-OROR | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-GORE | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-GROR | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM2A-DDR2-20-AQAQ | 20 (40 μL) | 200 μL |
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DDR2 Gene Summary
This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]
Gene Name: Discoidin Domain Receptor Tyrosine Kinase 2
Chromosome: CHR1: 162602227 -162750247
Locus: 1q23.3
KDM2A Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: Lysine Demethylase 2A
Chromosome: CHR11: 66886739 -67025550
Locus: 11q13.2
Gene Diseases
The KDM2A DDR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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