KCNQ5-DST Fusion FISH Probe
The KCNQ5-DST Fusion FISH Probe is used to confirm a fusion of the KCNQ5 and DST genes. The fusion of the KCNQ5 and DST genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KCNQ5-DST-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-RERE | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-REOR | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-REGO | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-REGR | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-REAQ | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-ORRE | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-OROR | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-ORGO | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-ORAQ | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-GORE | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-GOOR | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-GOGO | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-GOGR | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-GOAQ | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-GRRE | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-GROR | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-GRGO | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-GRGR | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-GRAQ | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-AQRE | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-AQOR | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-AQGO | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-AQGR | 20 (40 μL) | 200 μL |
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| KCNQ5-DST-20-AQAQ | 20 (40 μL) | 200 μL |
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DST Gene Summary
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
Gene Name: Dystonin
Chromosome: CHR6: 56322784 -56507694
Locus: 6p12.1
KCNQ5 Gene Summary
This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Name: Potassium Voltage-gated Channel Subfamily Q Member 5
Chromosome: CHR6: 73331570 -73908573
Locus: 6q13
Gene Diseases
The KCNQ5 DST Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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