KCNQ5-ALK Fusion FISH Probe
The KCNQ5-ALK Fusion FISH Probe is used to confirm a fusion of the KCNQ5 and ALK genes. The fusion of the KCNQ5 and ALK genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KCNQ5-ALK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-RERE | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-REOR | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-REGO | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-REGR | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-REAQ | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-ORRE | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-OROR | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-ORGO | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-ORAQ | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-GORE | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-GOOR | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-GOGO | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-GOGR | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-GOAQ | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-GRRE | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-GROR | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-GRGO | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-GRGR | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-GRAQ | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-AQRE | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-AQOR | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-AQGO | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-AQGR | 20 (40 μL) | 200 μL |
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| KCNQ5-ALK-20-AQAQ | 20 (40 μL) | 200 μL |
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ALK Gene Summary
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
Gene Name: ALK Receptor Tyrosine Kinase
Chromosome: CHR2: 29415639 -30144477
Locus: 2p23.2-p23.1
KCNQ5 Gene Summary
This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Name: Potassium Voltage-gated Channel Subfamily Q Member 5
Chromosome: CHR6: 73331570 -73908573
Locus: 6q13
Gene Diseases
The KCNQ5 ALK Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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