KCNQ3-LRRC6 Fusion FISH Probe
The KCNQ3-LRRC6 Fusion FISH Probe is used to confirm a fusion of the KCNQ3 and LRRC6 genes. The fusion of the KCNQ3 and LRRC6 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KCNQ3-LRRC6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-RERE | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-REOR | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-REGO | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-REGR | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-REAQ | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-ORRE | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-OROR | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-ORGO | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-ORAQ | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-GORE | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-GOOR | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-GOGO | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-GOGR | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-GOAQ | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-GRRE | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-GROR | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-GRGO | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-GRGR | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-GRAQ | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-AQRE | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-AQOR | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-AQGO | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-AQGR | 20 (40 μL) | 200 μL |
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| KCNQ3-LRRC6-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNQ3 Gene Summary
This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Potassium Voltage-gated Channel Subfamily Q Member 3
Chromosome: CHR8: 133133104 -133493004
Locus: 8q24.22
LRRC6 Gene Summary
The protein encoded by this gene contains several leucine-rich repeat domains and appears to be involved in the motility of cilia. Defects in this gene are a cause of primary ciliary dyskinesia-19 (CILD19). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 11 and 22. [provided by RefSeq, Apr 2016]
Gene Name: Leucine Rich Repeat Containing 6
Chromosome: CHR8: 133584446 -133687813
Locus: 8q24.22
Gene Diseases
The KCNQ3 LRRC6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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