KCNQ1-SCT Fusion FISH Probe
The KCNQ1-SCT Fusion FISH Probe is used to confirm a fusion of the KCNQ1 and SCT genes. The fusion of the KCNQ1 and SCT genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KCNQ1-SCT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-RERE | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-REOR | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-REGO | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-REGR | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-OROR | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-GORE | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-GROR | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| KCNQ1-SCT-20-AQAQ | 20 (40 μL) | 200 μL |
|
KCNQ1 Gene Summary
This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Potassium Voltage-gated Channel Subfamily Q Member 1
Chromosome: CHR11: 2466220 -2870340
Locus: 11p15.5-p15.4
SCT Gene Summary
This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]
Gene Name: Secretin
Chromosome: CHR11: 626312 -627173
Locus: 11p15.5
Gene Diseases
The KCNQ1 SCT Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|