KCNMA1-MSMB Fusion FISH Probe
The KCNMA1-MSMB Fusion FISH Probe is used to confirm a fusion of the KCNMA1 and MSMB genes. The fusion of the KCNMA1 and MSMB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KCNMA1-MSMB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-RERE | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-REOR | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-REGO | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-REGR | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-REAQ | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-ORRE | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-OROR | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-ORGO | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-ORAQ | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-GORE | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-GOOR | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-GOGO | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-GOGR | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-GOAQ | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-GRRE | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-GROR | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-GRGO | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-GRGR | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-GRAQ | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-AQRE | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-AQOR | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-AQGO | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-AQGR | 20 (40 μL) | 200 μL |
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| KCNMA1-MSMB-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNMA1 Gene Summary
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Potassium Calcium-activated Channel Subfamily M Alpha 1
Chromosome: CHR10: 78629358 -79397577
Locus: 10q22.3
MSMB Gene Summary
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Microseminoprotein Beta
Chromosome: CHR10: 51549552 -51562518
Locus: 10q11.22
Gene Diseases
The KCNMA1 MSMB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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