KCNK5-RUNX2 Fusion FISH Probe
The KCNK5-RUNX2 Fusion FISH Probe is used to confirm a fusion of the KCNK5 and RUNX2 genes. The fusion of the KCNK5 and RUNX2 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KCNK5-RUNX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-RERE | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-REOR | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-REGO | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-REGR | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-REAQ | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-ORRE | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-OROR | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-ORGO | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-ORAQ | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-GORE | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-GOOR | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-GOGO | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-GOGR | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-GOAQ | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-GRRE | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-GROR | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-GRGO | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-GRGR | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-GRAQ | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-AQRE | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-AQOR | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-AQGO | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-AQGR | 20 (40 μL) | 200 μL |
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| KCNK5-RUNX2-20-AQAQ | 20 (40 μL) | 200 μL |
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RUNX2 Gene Summary
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]
Gene Name: Runt Related Transcription Factor 2
Chromosome: CHR6: 45296053 -45518819
Locus: 6p21.1
KCNK5 Gene Summary
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
Gene Name: Potassium Two Pore Domain Channel Subfamily K Member 5
Chromosome: CHR6: 39156746 -39197251
Locus: 6p21.2
Gene Diseases
The KCNK5 RUNX2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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