KCNA6-C3AR1 Fusion FISH Probe
The KCNA6-C3AR1 Fusion FISH Probe is used to confirm a fusion of the KCNA6 and C3AR1 genes. The fusion of the KCNA6 and C3AR1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KCNA6-C3AR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-RERE | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-REOR | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-REGO | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-REGR | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-REAQ | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-ORRE | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-OROR | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-ORGO | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-GORE | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-GOOR | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-GOGO | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-GOGR | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-GRRE | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-GROR | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-GRGO | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-GRGR | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-AQRE | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-AQOR | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-AQGO | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-AQGR | 20 (40 μL) | 200 μL |
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| KCNA6-C3AR1-20-AQAQ | 20 (40 μL) | 200 μL |
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C3AR1 Gene Summary
C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
Gene Name: Complement C3a Receptor 1
Chromosome: CHR12: 8210918 -8218955
Locus: 12p13.31
KCNA6 Gene Summary
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]
Gene Name: Potassium Voltage-gated Channel Subfamily A Member 6
Chromosome: CHR12: 4918341 -4960278
Locus: 12p13.32
Gene Diseases
The KCNA6 C3AR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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