KATNA1-LATS1 Fusion FISH Probe
The KATNA1-LATS1 Fusion FISH Probe is used to confirm a fusion of the KATNA1 and LATS1 genes. The fusion of the KATNA1 and LATS1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KATNA1-LATS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-RERE | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-REOR | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-REGO | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-REGR | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-REAQ | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-ORRE | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-OROR | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-ORGO | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-GORE | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-GOOR | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-GOGO | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-GOGR | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-GRRE | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-GROR | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-GRGO | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-GRGR | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-AQRE | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-AQOR | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-AQGO | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-AQGR | 20 (40 μL) | 200 μL |
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| KATNA1-LATS1-20-AQAQ | 20 (40 μL) | 200 μL |
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LATS1 Gene Summary
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Gene Name: Large Tumor Suppressor Kinase 1
Chromosome: CHR6: 149982050 -150039392
Locus: 6q25.1
KATNA1 Gene Summary
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Gene Name: Katanin Catalytic Subunit A1
Chromosome: CHR6: 149916010 -149969940
Locus: 6q25.1
Gene Diseases
The KATNA1 LATS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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