KANK1-DOCK8 Fusion FISH Probe
The KANK1-DOCK8 Fusion FISH Probe is used to confirm a fusion of the KANK1 and DOCK8 genes. The fusion of the KANK1 and DOCK8 genes has been associated with Lung Adenocarcinoma, Breast Invasive Carcinoma, Colon Adenocarcinoma, and Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KANK1-DOCK8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-RERE | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-REOR | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-REGO | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-REGR | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-REAQ | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-ORRE | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-OROR | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-ORGO | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-ORAQ | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-GORE | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-GOOR | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-GOGO | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-GOGR | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-GOAQ | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-GRRE | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-GROR | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-GRGO | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-GRGR | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-GRAQ | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-AQRE | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-AQOR | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-AQGO | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-AQGR | 20 (40 μL) | 200 μL |
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| KANK1-DOCK8-20-AQAQ | 20 (40 μL) | 200 μL |
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KANK1 Gene Summary
The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]
Gene Name: KN Motif And Ankyrin Repeat Domains 1
Chromosome: CHR9: 504702 -746103
Locus: 9p24.3
DOCK8 Gene Summary
This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
Gene Name: Dedicator Of Cytokinesis 8
Chromosome: CHR9: 214864 -465259
Locus: 9p24.3
Gene Diseases
The KANK1 DOCK8 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Breast Invasive Carcinoma |
| Colon Adenocarcinoma |
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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