JUP-NDUFV1 Fusion FISH Probe
The JUP-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the JUP and NDUFV1 genes. The fusion of the JUP and NDUFV1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JUP-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| JUP-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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JUP Gene Summary
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
Gene Name: Junction Plakoglobin
Chromosome: CHR17: 39910858 -39942964
Locus: 17q21.2
NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
Gene Diseases
The JUP NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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