JMJD1C-NRBF2 Fusion FISH Probe
The JMJD1C-NRBF2 Fusion FISH Probe is used to confirm a fusion of the JMJD1C and NRBF2 genes. The fusion of the JMJD1C and NRBF2 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JMJD1C-NRBF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-RERE | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-REOR | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-REGO | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-REGR | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-REAQ | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-ORRE | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-OROR | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-ORGO | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-GORE | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-GOOR | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-GOGO | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-GOGR | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-GRRE | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-GROR | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-GRGO | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-GRGR | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-AQRE | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-AQOR | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-AQGO | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-AQGR | 20 (40 μL) | 200 μL |
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| JMJD1C-NRBF2-20-AQAQ | 20 (40 μL) | 200 μL |
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NRBF2 Gene Summary
The Nuclear Receptor Binding Factor 2 (NRBF2) gene is located on chr10 :64893006-64914786 at 10q21.3.
Gene Name: Nuclear Receptor Binding Factor 2
Chromosome: CHR10: 64893006 -64914786
Locus: 10q21.3
JMJD1C Gene Summary
The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: Jumonji Domain Containing 1C
Chromosome: CHR10: 64926987 -65225722
Locus: 10q21.3
Gene Diseases
The JMJD1C NRBF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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