JARID2-PPP1R10 Fusion FISH Probe
The JARID2-PPP1R10 Fusion FISH Probe is used to confirm a fusion of the JARID2 and PPP1R10 genes. The fusion of the JARID2 and PPP1R10 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JARID2-PPP1R10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-RERE | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-REOR | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-REGO | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-REGR | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-REAQ | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-ORRE | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-OROR | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-ORGO | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-ORAQ | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-GORE | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-GOOR | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-GOGO | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-GOGR | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-GOAQ | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-GRRE | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-GROR | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-GRGO | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-GRGR | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-GRAQ | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-AQRE | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-AQOR | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-AQGO | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-AQGR | 20 (40 μL) | 200 μL |
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| JARID2-PPP1R10-20-AQAQ | 20 (40 μL) | 200 μL |
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JARID2 Gene Summary
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Gene Name: Jumonji And AT-rich Interaction Domain Containing 2
Chromosome: CHR6: 15246526 -15522253
Locus: 6p22.3
PPP1R10 Gene Summary
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 10
Chromosome: CHR6_mcf_hap5: 1950036 -1966876
Locus: 6p21.33
Gene Diseases
The JARID2 PPP1R10 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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