JARID2-NEDD9 Fusion FISH Probe
The JARID2-NEDD9 Fusion FISH Probe is used to confirm a fusion of the JARID2 and NEDD9 genes. The fusion of the JARID2 and NEDD9 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JARID2-NEDD9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-RERE | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-REOR | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-REGO | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-REGR | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-REAQ | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-ORRE | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-OROR | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-ORGO | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-ORAQ | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-GORE | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-GOOR | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-GOGO | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-GOGR | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-GOAQ | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-GRRE | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-GROR | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-GRGO | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-GRGR | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-GRAQ | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-AQRE | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-AQOR | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-AQGO | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-AQGR | 20 (40 μL) | 200 μL |
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| JARID2-NEDD9-20-AQAQ | 20 (40 μL) | 200 μL |
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JARID2 Gene Summary
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Gene Name: Jumonji And AT-rich Interaction Domain Containing 2
Chromosome: CHR6: 15246526 -15522253
Locus: 6p22.3
NEDD9 Gene Summary
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Name: Neural Precursor Cell Expressed, Developmentally Down-regulated 9
Chromosome: CHR6: 11183530 -11382581
Locus: 6p24.2
Gene Diseases
The JARID2 NEDD9 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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