JARID2-HFE Fusion FISH Probe
The JARID2-HFE Fusion FISH Probe is used to confirm a fusion of the JARID2 and HFE genes. The fusion of the JARID2 and HFE genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JARID2-HFE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-RERE | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-REOR | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-REGO | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-REGR | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-REAQ | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-ORRE | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-OROR | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-ORGO | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-ORAQ | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-GORE | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-GOOR | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-GOGO | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-GOGR | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-GOAQ | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-GRRE | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-GROR | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-GRGO | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-GRGR | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-GRAQ | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-AQRE | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-AQOR | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-AQGO | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-AQGR | 20 (40 μL) | 200 μL |
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| JARID2-HFE-20-AQAQ | 20 (40 μL) | 200 μL |
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HFE Gene Summary
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Hemochromatosis
Chromosome: CHR6: 26087508 -26095469
Locus: 6p22.2
JARID2 Gene Summary
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Gene Name: Jumonji And AT-rich Interaction Domain Containing 2
Chromosome: CHR6: 15246526 -15522253
Locus: 6p22.3
Gene Diseases
The JARID2 HFE Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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