JARID2-ATM Fusion FISH Probe
The JARID2-ATM Fusion FISH Probe is used to confirm a fusion of the JARID2 and ATM genes. The fusion of the JARID2 and ATM genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| JARID2-ATM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-RERE | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-REOR | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-REGO | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-REGR | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-OROR | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-GORE | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-GROR | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| JARID2-ATM-20-AQAQ | 20 (40 μL) | 200 μL |
|
ATM Gene Summary
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Gene Name: ATM Serine/threonine Kinase
Chromosome: CHR11: 108093558 -108239826
Locus: 11q22.3
JARID2 Gene Summary
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Gene Name: Jumonji And AT-rich Interaction Domain Containing 2
Chromosome: CHR6: 15246526 -15522253
Locus: 6p22.3
Gene Diseases
The JARID2 ATM Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|