JAK2-GLDC Fusion FISH Probe
The JAK2-GLDC Fusion FISH Probe is used to confirm a fusion of the JAK2 and GLDC genes. The fusion of the JAK2 and GLDC genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JAK2-GLDC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-RERE | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-REOR | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-REGO | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-REGR | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-REAQ | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-ORRE | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-OROR | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-ORGO | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-ORAQ | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-GORE | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-GOOR | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-GOGO | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-GOGR | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-GOAQ | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-GRRE | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-GROR | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-GRGO | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-GRGR | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-GRAQ | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-AQRE | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-AQOR | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-AQGO | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-AQGR | 20 (40 μL) | 200 μL |
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| JAK2-GLDC-20-AQAQ | 20 (40 μL) | 200 μL |
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GLDC Gene Summary
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
Gene Name: Glycine Decarboxylase
Chromosome: CHR9: 6532463 -6645692
Locus: 9p24.1
JAK2 Gene Summary
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
Gene Name: Janus Kinase 2
Chromosome: CHR9: 4985244 -5128183
Locus: 9p24.1
Gene Diseases
The JAK2 GLDC Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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