JAK2-DOCK8 Fusion FISH Probe
The JAK2-DOCK8 Fusion FISH Probe is used to confirm a fusion of the JAK2 and DOCK8 genes. The fusion of the JAK2 and DOCK8 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| JAK2-DOCK8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-RERE | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-REOR | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-REGO | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-REGR | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-REAQ | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-ORRE | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-OROR | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-ORGO | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-ORAQ | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-GORE | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-GOOR | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-GOGO | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-GOGR | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-GOAQ | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-GRRE | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-GROR | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-GRGO | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-GRGR | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-GRAQ | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-AQRE | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-AQOR | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-AQGO | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-AQGR | 20 (40 μL) | 200 μL |
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| JAK2-DOCK8-20-AQAQ | 20 (40 μL) | 200 μL |
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JAK2 Gene Summary
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
Gene Name: Janus Kinase 2
Chromosome: CHR9: 4985244 -5128183
Locus: 9p24.1
DOCK8 Gene Summary
This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
Gene Name: Dedicator Of Cytokinesis 8
Chromosome: CHR9: 214864 -465259
Locus: 9p24.3
Gene Diseases
The JAK2 DOCK8 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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