ITSN2-KIDINS220 Fusion FISH Probe
The ITSN2-KIDINS220 Fusion FISH Probe is used to confirm a fusion of the ITSN2 and KIDINS220 genes. The fusion of the ITSN2 and KIDINS220 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITSN2-KIDINS220-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-RERE | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-REOR | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-REGO | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-REGR | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-REAQ | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-ORRE | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-OROR | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-ORGO | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-GORE | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-GOOR | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-GOGO | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-GOGR | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-GRRE | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-GROR | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-GRGO | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-GRGR | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-AQRE | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-AQOR | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-AQGO | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-AQGR | 20 (40 μL) | 200 μL |
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| ITSN2-KIDINS220-20-AQAQ | 20 (40 μL) | 200 μL |
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ITSN2 Gene Summary
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]
Gene Name: Intersectin 2
Chromosome: CHR2: 24425734 -24583397
Locus: 2p23.3
KIDINS220 Gene Summary
This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Gene Name: Kinase D Interacting Substrate 220
Chromosome: CHR2: 8868986 -8977755
Locus: 2p25.1
Gene Diseases
The ITSN2 KIDINS220 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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