ITPR3-SYNGAP1 Fusion FISH Probe
The ITPR3-SYNGAP1 Fusion FISH Probe is used to confirm a fusion of the ITPR3 and SYNGAP1 genes. The fusion of the ITPR3 and SYNGAP1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITPR3-SYNGAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-RERE | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-REOR | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-REGO | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-REGR | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-OROR | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-GORE | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-GROR | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| ITPR3-SYNGAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPR3 Gene Summary
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
Gene Name: Inositol 1,4,5-trisphosphate Receptor Type 3
Chromosome: CHR6: 33589155 -33664348
Locus: 6p21.31
SYNGAP1 Gene Summary
This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Name: Synaptic Ras GTPase Activating Protein 1
Chromosome: CHR6: 33387846 -33421466
Locus: 6p21.32
Gene Diseases
The ITPR3 SYNGAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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