ITPR2-RASSF3 Fusion FISH Probe
The ITPR2-RASSF3 Fusion FISH Probe is used to confirm a fusion of the ITPR2 and RASSF3 genes. The fusion of the ITPR2 and RASSF3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITPR2-RASSF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-RERE | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-REOR | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-REGO | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-REGR | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-REAQ | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-ORRE | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-OROR | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-ORGO | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-GORE | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-GOOR | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-GOGO | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-GOGR | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-GRRE | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-GROR | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-GRGO | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-GRGR | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-AQRE | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-AQOR | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-AQGO | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-AQGR | 20 (40 μL) | 200 μL |
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| ITPR2-RASSF3-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPR2 Gene Summary
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Gene Name: Inositol 1,4,5-trisphosphate Receptor Type 2
Chromosome: CHR12: 26488284 -26986131
Locus: 12p11.23
RASSF3 Gene Summary
The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003]
Gene Name: Ras Association Domain Family Member 3
Chromosome: CHR12: 65004292 -65091347
Locus: 12q14.2
Gene Diseases
The ITPR2 RASSF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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