ITPR2-RAD17 Fusion FISH Probe
The ITPR2-RAD17 Fusion FISH Probe is used to confirm a fusion of the ITPR2 and RAD17 genes. The fusion of the ITPR2 and RAD17 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITPR2-RAD17-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-RERE | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-REOR | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-REGO | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-REGR | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-REAQ | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-ORRE | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-OROR | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-ORGO | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-GORE | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-GOOR | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-GOGO | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-GOGR | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-GRRE | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-GROR | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-GRGO | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-GRGR | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-AQRE | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-AQOR | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-AQGO | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-AQGR | 20 (40 μL) | 200 μL |
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| ITPR2-RAD17-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPR2 Gene Summary
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Gene Name: Inositol 1,4,5-trisphosphate Receptor Type 2
Chromosome: CHR12: 26488284 -26986131
Locus: 12p11.23
RAD17 Gene Summary
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
Gene Name: RAD17 Checkpoint Clamp Loader Component
Chromosome: CHR5: 68665123 -68710630
Locus: 5q13.2
Gene Diseases
The ITPR2 RAD17 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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