ITPR2-DCDC2 Fusion FISH Probe
The ITPR2-DCDC2 Fusion FISH Probe is used to confirm a fusion of the ITPR2 and DCDC2 genes. The fusion of the ITPR2 and DCDC2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITPR2-DCDC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-RERE | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-REOR | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-REGO | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-REGR | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-REAQ | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-ORRE | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-OROR | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-ORGO | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-GORE | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-GOOR | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-GOGO | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-GOGR | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-GRRE | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-GROR | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-GRGO | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-GRGR | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-AQRE | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-AQOR | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-AQGO | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-AQGR | 20 (40 μL) | 200 μL |
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| ITPR2-DCDC2-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPR2 Gene Summary
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Gene Name: Inositol 1,4,5-trisphosphate Receptor Type 2
Chromosome: CHR12: 26488284 -26986131
Locus: 12p11.23
DCDC2 Gene Summary
This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Name: Doublecortin Domain Containing 2
Chromosome: CHR6: 24171982 -24383520
Locus: 6p22.3
Gene Diseases
The ITPR2 DCDC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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