ITPR2-CLIC1 Fusion FISH Probe
The ITPR2-CLIC1 Fusion FISH Probe is used to confirm a fusion of the ITPR2 and CLIC1 genes. The fusion of the ITPR2 and CLIC1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITPR2-CLIC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-RERE | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-REOR | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-REGO | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-REGR | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-REAQ | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-ORRE | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-OROR | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-ORGO | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-GORE | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-GOOR | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-GOGO | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-GOGR | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-GRRE | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-GROR | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-GRGO | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-GRGR | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-AQRE | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-AQOR | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-AQGO | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-AQGR | 20 (40 μL) | 200 μL |
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| ITPR2-CLIC1-20-AQAQ | 20 (40 μL) | 200 μL |
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CLIC1 Gene Summary
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
Gene Name: Chloride Intracellular Channel 1
Chromosome: CHR6_qbl_hap6: 2991987 -2997979
Locus: 6p21.33
ITPR2 Gene Summary
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Gene Name: Inositol 1,4,5-trisphosphate Receptor Type 2
Chromosome: CHR12: 26488284 -26986131
Locus: 12p11.23
Gene Diseases
The ITPR2 CLIC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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