ITPR2-CLEC2A Fusion FISH Probe
The ITPR2-CLEC2A Fusion FISH Probe is used to confirm a fusion of the ITPR2 and CLEC2A genes. The fusion of the ITPR2 and CLEC2A genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITPR2-CLEC2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-RERE | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-REOR | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-REGO | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-REGR | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-REAQ | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-ORRE | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-OROR | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-ORGO | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-GORE | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-GOOR | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-GOGO | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-GOGR | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-GRRE | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-GROR | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-GRGO | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-GRGR | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-AQRE | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-AQOR | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-AQGO | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-AQGR | 20 (40 μL) | 200 μL |
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| ITPR2-CLEC2A-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPR2 Gene Summary
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Gene Name: Inositol 1,4,5-trisphosphate Receptor Type 2
Chromosome: CHR12: 26488284 -26986131
Locus: 12p11.23
CLEC2A Gene Summary
CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]
Gene Name: C-type Lectin Domain Family 2 Member A
Chromosome: CHR12: 10065825 -10084980
Locus: 12p13.31
Gene Diseases
The ITPR2 CLEC2A Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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