ITPR2-ADIPOR2 Fusion FISH Probe
The ITPR2-ADIPOR2 Fusion FISH Probe is used to confirm a fusion of the ITPR2 and ADIPOR2 genes. The fusion of the ITPR2 and ADIPOR2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITPR2-ADIPOR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-RERE | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-REOR | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-REGO | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-REGR | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-REAQ | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-ORRE | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-OROR | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-ORGO | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-GORE | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-GOOR | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-GOGO | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-GOGR | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-GRRE | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-GROR | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-GRGO | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-GRGR | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-AQRE | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-AQOR | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-AQGO | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-AQGR | 20 (40 μL) | 200 μL |
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| ITPR2-ADIPOR2-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPR2 Gene Summary
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Gene Name: Inositol 1,4,5-trisphosphate Receptor Type 2
Chromosome: CHR12: 26488284 -26986131
Locus: 12p11.23
ADIPOR2 Gene Summary
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
Gene Name: Adiponectin Receptor 2
Chromosome: CHR12: 1800246 -1897845
Locus: 12p13.33
Gene Diseases
The ITPR2 ADIPOR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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