ITM2B-RPL30 Fusion FISH Probe
The ITM2B-RPL30 Fusion FISH Probe is used to confirm a fusion of the ITM2B and RPL30 genes. The fusion of the ITM2B and RPL30 genes has been associated with Kidney Renal Papillary Cell Carcinoma, Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma, Kidney Renal Papillary Cell Carcinoma, and Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITM2B-RPL30-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-RERE | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-REOR | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-REGO | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-REGR | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-REAQ | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-ORRE | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-OROR | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-ORGO | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-GORE | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-GOOR | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-GOGO | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-GOGR | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-GRRE | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-GROR | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-GRGO | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-GRGR | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-AQRE | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-AQOR | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-AQGO | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-AQGR | 20 (40 μL) | 200 μL |
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| ITM2B-RPL30-20-AQAQ | 20 (40 μL) | 200 μL |
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RPL30 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30E family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the U72 small nucleolar RNA gene, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein L30
Chromosome: CHR8: 99053937 -99057818
Locus: 8q22.2
ITM2B Gene Summary
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Gene Name: Integral Membrane Protein 2B
Chromosome: CHR13: 48807273 -48836232
Locus: 13q14.2
Gene Diseases
The ITM2B RPL30 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
| Kidney Renal Papillary Cell Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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