ITM2B-ESD Fusion FISH Probe
The ITM2B-ESD Fusion FISH Probe is used to confirm a fusion of the ITM2B and ESD genes. The fusion of the ITM2B and ESD genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITM2B-ESD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-RERE | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-REOR | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-REGO | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-REGR | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-REAQ | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-ORRE | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-OROR | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-ORGO | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-GORE | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-GOOR | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-GOGO | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-GOGR | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-GRRE | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-GROR | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-GRGO | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-GRGR | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-AQRE | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-AQOR | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-AQGO | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-AQGR | 20 (40 μL) | 200 μL |
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| ITM2B-ESD-20-AQAQ | 20 (40 μL) | 200 μL |
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ESD Gene Summary
This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009]
Gene Name: Esterase D
Chromosome: CHR13: 47345390 -47371367
Locus: 13q14.2
ITM2B Gene Summary
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Gene Name: Integral Membrane Protein 2B
Chromosome: CHR13: 48807273 -48836232
Locus: 13q14.2
Gene Diseases
The ITM2B ESD Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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