ITM2B-CBS Fusion FISH Probe
The ITM2B-CBS Fusion FISH Probe is used to confirm a fusion of the ITM2B and CBS genes. The fusion of the ITM2B and CBS genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITM2B-CBS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-RERE | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-REOR | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-REGO | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-REGR | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-REAQ | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-ORRE | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-OROR | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-ORGO | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-GORE | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-GOOR | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-GOGO | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-GOGR | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-GRRE | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-GROR | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-GRGO | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-GRGR | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-AQRE | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-AQOR | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-AQGO | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-AQGR | 20 (40 μL) | 200 μL |
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| ITM2B-CBS-20-AQAQ | 20 (40 μL) | 200 μL |
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CBS Gene Summary
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: Cystathionine-beta-synthase
Chromosome: CHR21: 44473300 -44496472
Locus: 21q22.3
ITM2B Gene Summary
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Gene Name: Integral Membrane Protein 2B
Chromosome: CHR13: 48807273 -48836232
Locus: 13q14.2
Gene Diseases
The ITM2B CBS Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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