ITM2B-ARFGEF2 Fusion FISH Probe
The ITM2B-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the ITM2B and ARFGEF2 genes. The fusion of the ITM2B and ARFGEF2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITM2B-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| ITM2B-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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ITM2B Gene Summary
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Gene Name: Integral Membrane Protein 2B
Chromosome: CHR13: 48807273 -48836232
Locus: 13q14.2
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The ITM2B ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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