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ITGB4-PLEKHB2 Fusion FISH Probe

The ITGB4-PLEKHB2 Fusion FISH Probe is used to confirm a fusion of the ITGB4 and PLEKHB2 genes. The fusion of the ITGB4 and PLEKHB2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ITGB4-PLEKHB2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-RERE 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-REOR 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-REGO 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-REGR 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-REAQ 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-ORRE 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-OROR 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-ORGO 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-ORAQ 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-GORE 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-GOOR 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-GOGO 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-GOGR 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-GOAQ 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-GRRE 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-GROR 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-GRGO 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-GRGR 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-GRAQ 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-AQRE 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-AQOR 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-AQGO 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-AQGR 20 (40 μL) 200 μL
ITGB4-PLEKHB2-20-AQAQ 20 (40 μL) 200 μL

ITGB4 Gene Summary

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Integrin Subunit Beta 4

Chromosome: CHR17: 73717515 -73753899

Locus: 17q25.1

PLEKHB2 Gene Summary

The Pleckstrin Homology Domain Containing B2 (PLEKHB2) gene is located on chr2 :131862419-131907425 at 2q21.1.

Gene Name: Pleckstrin Homology Domain Containing B2

Chromosome: CHR2: 131862419 -131907425

Locus: 2q21.1

Gene Diseases

The ITGB4 PLEKHB2 Fusion has been associated with the following diseases:

Disease Name
Head And Neck Squamous Cell Carcinoma 

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.