ITGB4-OTOP2 Fusion FISH Probe
The ITGB4-OTOP2 Fusion FISH Probe is used to confirm a fusion of the ITGB4 and OTOP2 genes. The fusion of the ITGB4 and OTOP2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITGB4-OTOP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-RERE | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-REOR | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-REGO | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-REGR | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-REAQ | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-ORRE | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-OROR | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-ORGO | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-GORE | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-GOOR | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-GOGO | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-GOGR | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-GRRE | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-GROR | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-GRGO | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-GRGR | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-AQRE | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-AQOR | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-AQGO | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-AQGR | 20 (40 μL) | 200 μL |
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| ITGB4-OTOP2-20-AQAQ | 20 (40 μL) | 200 μL |
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ITGB4 Gene Summary
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Integrin Subunit Beta 4
Chromosome: CHR17: 73717515 -73753899
Locus: 17q25.1
OTOP2 Gene Summary
The Otopetrin 2 (OTOP2) gene is located on chr17 :72920369-72930006 at 17q25.1.
Gene Name: Otopetrin 2
Chromosome: CHR17: 72920369 -72930006
Locus: 17q25.1
Gene Diseases
The ITGB4 OTOP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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