ITGAV-PDE11A Fusion FISH Probe
The ITGAV-PDE11A Fusion FISH Probe is used to confirm a fusion of the ITGAV and PDE11A genes. The fusion of the ITGAV and PDE11A genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITGAV-PDE11A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-RERE | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-REOR | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-REGO | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-REGR | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-REAQ | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-ORRE | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-OROR | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-ORGO | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-GORE | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-GOOR | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-GOGO | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-GOGR | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-GRRE | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-GROR | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-GRGO | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-GRGR | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-AQRE | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-AQOR | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-AQGO | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-AQGR | 20 (40 μL) | 200 μL |
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| ITGAV-PDE11A-20-AQAQ | 20 (40 μL) | 200 μL |
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ITGAV Gene Summary
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Gene Name: Integrin Subunit Alpha V
Chromosome: CHR2: 187454789 -187545628
Locus: 2q32.1
PDE11A Gene Summary
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Phosphodiesterase 11A
Chromosome: CHR2: 178487976 -178973066
Locus: 2q31.2
Gene Diseases
The ITGAV PDE11A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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