ITGA8-FAM188A Fusion FISH Probe
The ITGA8-FAM188A Fusion FISH Probe is used to confirm a fusion of the ITGA8 and FAM188A genes. The fusion of the ITGA8 and FAM188A genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITGA8-FAM188A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-RERE | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-REOR | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-REGO | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-REGR | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-REAQ | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-ORRE | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-OROR | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-ORGO | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-GORE | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-GOOR | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-GOGO | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-GOGR | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-GRRE | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-GROR | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-GRGO | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-GRGR | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-AQRE | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-AQOR | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-AQGO | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-AQGR | 20 (40 μL) | 200 μL |
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| ITGA8-FAM188A-20-AQAQ | 20 (40 μL) | 200 μL |
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ITGA8 Gene Summary
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
Gene Name: Integrin Subunit Alpha 8
Chromosome: CHR10: 15559087 -15761770
Locus: 10p13
Gene Diseases
The ITGA8 FAM188A Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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