ITGA6-UBE3B Fusion FISH Probe
The ITGA6-UBE3B Fusion FISH Probe is used to confirm a fusion of the ITGA6 and UBE3B genes. The fusion of the ITGA6 and UBE3B genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITGA6-UBE3B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-RERE | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-REOR | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-REGO | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-REGR | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-REAQ | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-ORRE | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-OROR | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-ORGO | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-GORE | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-GOOR | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-GOGO | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-GOGR | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-GRRE | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-GROR | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-GRGO | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-GRGR | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-AQRE | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-AQOR | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-AQGO | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-AQGR | 20 (40 μL) | 200 μL |
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| ITGA6-UBE3B-20-AQAQ | 20 (40 μL) | 200 μL |
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ITGA6 Gene Summary
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Integrin Subunit Alpha 6
Chromosome: CHR2: 173292313 -173371181
Locus: 2q31.1
UBE3B Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Ubiquitin Protein Ligase E3B
Chromosome: CHR12: 109915438 -109974507
Locus: 12q24.11
Gene Diseases
The ITGA6 UBE3B Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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