ITGA6-MYO3B Fusion FISH Probe
The ITGA6-MYO3B Fusion FISH Probe is used to confirm a fusion of the ITGA6 and MYO3B genes. The fusion of the ITGA6 and MYO3B genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITGA6-MYO3B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-RERE | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-REOR | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-REGO | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-REGR | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-REAQ | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-ORRE | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-OROR | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-ORGO | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-GORE | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-GOOR | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-GOGO | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-GOGR | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-GRRE | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-GROR | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-GRGO | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-GRGR | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-AQRE | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-AQOR | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-AQGO | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-AQGR | 20 (40 μL) | 200 μL |
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| ITGA6-MYO3B-20-AQAQ | 20 (40 μL) | 200 μL |
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ITGA6 Gene Summary
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Integrin Subunit Alpha 6
Chromosome: CHR2: 173292313 -173371181
Locus: 2q31.1
MYO3B Gene Summary
This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Gene Name: Myosin IIIB
Chromosome: CHR2: 171034654 -171511674
Locus: 2q31.1
Gene Diseases
The ITGA6 MYO3B Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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