ITGA6-HAT1 Fusion FISH Probe
The ITGA6-HAT1 Fusion FISH Probe is used to confirm a fusion of the ITGA6 and HAT1 genes. The fusion of the ITGA6 and HAT1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITGA6-HAT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-RERE | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-REOR | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-REGO | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-REGR | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-REAQ | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-ORRE | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-OROR | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-ORGO | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-GORE | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-GOOR | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-GOGO | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-GOGR | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-GRRE | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-GROR | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-GRGO | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-GRGR | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-AQRE | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-AQOR | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-AQGO | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-AQGR | 20 (40 μL) | 200 μL |
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| ITGA6-HAT1-20-AQAQ | 20 (40 μL) | 200 μL |
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ITGA6 Gene Summary
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Integrin Subunit Alpha 6
Chromosome: CHR2: 173292313 -173371181
Locus: 2q31.1
HAT1 Gene Summary
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
Gene Name: Histone Acetyltransferase 1
Chromosome: CHR2: 172778934 -172848600
Locus: 2q31.1
Gene Diseases
The ITGA6 HAT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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