ITGA3-NDUFV1 Fusion FISH Probe
The ITGA3-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the ITGA3 and NDUFV1 genes. The fusion of the ITGA3 and NDUFV1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITGA3-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| ITGA3-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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ITGA3 Gene Summary
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
Gene Name: Integrin Subunit Alpha 3
Chromosome: CHR17: 48133339 -48167849
Locus: 17q21.33
NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
Gene Diseases
The ITGA3 NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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