ITCH-TSHZ2 Fusion FISH Probe
The ITCH-TSHZ2 Fusion FISH Probe is used to confirm a fusion of the ITCH and TSHZ2 genes. The fusion of the ITCH and TSHZ2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITCH-TSHZ2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-RERE | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-REOR | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-REGO | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-REGR | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-REAQ | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-ORRE | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-OROR | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-ORGO | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-GORE | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-GOOR | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-GOGO | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-GOGR | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-GRRE | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-GROR | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-GRGO | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-GRGR | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-AQRE | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-AQOR | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-AQGO | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-AQGR | 20 (40 μL) | 200 μL |
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| ITCH-TSHZ2-20-AQAQ | 20 (40 μL) | 200 μL |
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ITCH Gene Summary
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Itchy E3 Ubiquitin Protein Ligase
Chromosome: CHR20: 32951061 -33099197
Locus: 20q11.22
TSHZ2 Gene Summary
This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Gene Name: Teashirt Zinc Finger Homeobox 2
Chromosome: CHR20: 51588945 -52111869
Locus: 20q13.2
Gene Diseases
The ITCH TSHZ2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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