ITCH-SRC Fusion FISH Probe
The ITCH-SRC Fusion FISH Probe is used to confirm a fusion of the ITCH and SRC genes. The fusion of the ITCH and SRC genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITCH-SRC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-RERE | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-REOR | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-REGO | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-REGR | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-REAQ | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-ORRE | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-OROR | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-ORGO | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-GORE | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-GOOR | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-GOGO | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-GOGR | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-GRRE | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-GROR | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-GRGO | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-GRGR | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-AQRE | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-AQOR | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-AQGO | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-AQGR | 20 (40 μL) | 200 μL |
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| ITCH-SRC-20-AQAQ | 20 (40 μL) | 200 μL |
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SRC Gene Summary
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: SRC Proto-oncogene, Non-receptor Tyrosine Kinase
Chromosome: CHR20: 35973087 -36033821
Locus: 20q11.23
ITCH Gene Summary
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Itchy E3 Ubiquitin Protein Ligase
Chromosome: CHR20: 32951061 -33099197
Locus: 20q11.22
Gene Diseases
The ITCH SRC Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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