ITCH-MYL9 Fusion FISH Probe
The ITCH-MYL9 Fusion FISH Probe is used to confirm a fusion of the ITCH and MYL9 genes. The fusion of the ITCH and MYL9 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITCH-MYL9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-RERE | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-REOR | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-REGO | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-REGR | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-REAQ | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-ORRE | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-OROR | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-ORGO | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-GORE | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-GOOR | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-GOGO | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-GOGR | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-GRRE | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-GROR | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-GRGO | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-GRGR | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-AQRE | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-AQOR | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-AQGO | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-AQGR | 20 (40 μL) | 200 μL |
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| ITCH-MYL9-20-AQAQ | 20 (40 μL) | 200 μL |
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MYL9 Gene Summary
Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Myosin Light Chain 9
Chromosome: CHR20: 35169896 -35178226
Locus: 20q11.23
ITCH Gene Summary
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Itchy E3 Ubiquitin Protein Ligase
Chromosome: CHR20: 32951061 -33099197
Locus: 20q11.22
Gene Diseases
The ITCH MYL9 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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