ITCH-JMJD4 Fusion FISH Probe
The ITCH-JMJD4 Fusion FISH Probe is used to confirm a fusion of the ITCH and JMJD4 genes. The fusion of the ITCH and JMJD4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITCH-JMJD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-RERE | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-REOR | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-REGO | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-REGR | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-REAQ | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-ORRE | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-OROR | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-ORGO | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-GORE | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-GOOR | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-GOGO | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-GOGR | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-GRRE | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-GROR | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-GRGO | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-GRGR | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-AQRE | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-AQOR | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-AQGO | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-AQGR | 20 (40 μL) | 200 μL |
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| ITCH-JMJD4-20-AQAQ | 20 (40 μL) | 200 μL |
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JMJD4 Gene Summary
The Jumonji Domain Containing 4 (JMJD4) gene is located on chr1 :227918889-227923112 at 1q42.13.
Gene Name: Jumonji Domain Containing 4
Chromosome: CHR1: 227918889 -227923112
Locus: 1q42.13
ITCH Gene Summary
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Itchy E3 Ubiquitin Protein Ligase
Chromosome: CHR20: 32951061 -33099197
Locus: 20q11.22
Gene Diseases
The ITCH JMJD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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