ITCH-ARFGAP1 Fusion FISH Probe
The ITCH-ARFGAP1 Fusion FISH Probe is used to confirm a fusion of the ITCH and ARFGAP1 genes. The fusion of the ITCH and ARFGAP1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ITCH-ARFGAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-RERE | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-REOR | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-REGO | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-REGR | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-OROR | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-GORE | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-GROR | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| ITCH-ARFGAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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ARFGAP1 Gene Summary
The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: ADP Ribosylation Factor GTPase Activating Protein 1
Chromosome: CHR20: 61904164 -61921142
Locus: 20q13.33
ITCH Gene Summary
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Itchy E3 Ubiquitin Protein Ligase
Chromosome: CHR20: 32951061 -33099197
Locus: 20q11.22
Gene Diseases
The ITCH ARFGAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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