ISY1-MASP1 Fusion FISH Probe
The ISY1-MASP1 Fusion FISH Probe is used to confirm a fusion of the ISY1 and MASP1 genes. The fusion of the ISY1 and MASP1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ISY1-MASP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-RERE | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-REOR | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-REGO | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-REGR | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-REAQ | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-ORRE | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-OROR | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-ORGO | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-GORE | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-GOOR | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-GOGO | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-GOGR | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-GRRE | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-GROR | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-GRGO | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-GRGR | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-AQRE | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-AQOR | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-AQGO | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-AQGR | 20 (40 μL) | 200 μL |
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| ISY1-MASP1-20-AQAQ | 20 (40 μL) | 200 μL |
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MASP1 Gene Summary
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Gene Name: Mannan Binding Lectin Serine Peptidase 1
Chromosome: CHR3: 186933872 -187009810
Locus: 3q27.3
ISY1 Gene Summary
The ISY1 Splicing Factor Homolog (ISY1) gene is located on chr3 :128846258-128880073 at 3q21.3.
Gene Name: ISY1 Splicing Factor Homolog
Chromosome: CHR3: 128846258 -128880073
Locus: 3q21.3
Gene Diseases
The ISY1 MASP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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